The first thing the virus is going to do is start infecting your airway epithelial cells, your lung cells, if you will. If you get exposed to an influenza virus, you breathe in the virus.
Let’s take the example of an influenza virus. In fact, the research papers that were coming out as all of this craziness was starting that really helped illuminate how the immune system functions to a certain degree. In fact, through the course of the pandemic, some of this even became more relevant.
What does that mean to talk about the microbiome as the eyes and ears of the immune system? There’s evidence of both of those, and we can unpack each of those two claims a little bit more.Īri: Yes, let’s do that. Number two, the immune system to a certain degree would cease to function completely without the microbiome. The immune system will be blind and deaf, if you will, without the microbiome. The two claims that I tend to make with regards to the microbiome and the immune system, claim number one, is that the microbiome are the eyes and ears of the immune system. The immune system gets translational messages from the microbes that are at the outside. The immune system is not on the outside dictating what’s happening in the environment. The microbiome are acting as the eyes and the ears, the microbiome is translating the outside world to the immune system, because the immune system is not in the forefront.
That conduit, that translation of what’s in the environment and what does the immune system need to protect the host from, all of that messaging comes from the microbiome. When you come back, it’s going to change to adapt to the environment around you because the job of the immune system is to protect the host, and the dangers to the host change based on the environment. If you leave the US and you go to Costa Rica, for example, for six months, your immune system’s going to change during that time. Another thing to keep in mind is that the immune system is one of the only components of the body that is continuously adapting to the environment.Īs your environment changes, your immune function, your immune capabilities, restrictions, actions, all of that change. The microbiome is refereeing the immune system. Number two, that the microbiome provides the thresholds signaling for the immune system to allow the immune system to understand when to react and when not to react. Number one, that the microbiome acts as the eyes and ears of the immune system. There are a couple of things that are important to keep in mind. They’re just different components of the same ecological system. Kiran: Yes, to really think about it, I think one of the things we want to establish is that the microbiome and the immune system are really one and the same.
Explain that to people what’s going on there. Let’s jump into, I guess, starting more broad with the relationship of the microbiome to immune function. Especially now, as we were just talking about before, starting to record there’s been a number of studies that have come out on that relationship.
WORKING SPORE ACTIVATION KEY UPDATE
Ari: Now that we’re a year and a half into this whole COVID thing, I thought it’d be a good time to do an update on the relationship of the microbiome to immune function.
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